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P3076

Sigma-Aldrich

Platelet-Derived Growth Factor-AA human

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

PDGF−AA

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About This Item

MDL-Nummer:
MFCD00081862
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE and HPLC)

Form

lyophilized powder

Wirksamkeit

1.0-3.0 ng/mL ED50

Qualität

endotoxin tested

Mol-Gew.

28.5 kDa (containing 250 amino acid residues)

Verpackung

pkg of 10 μg
pkg of 50 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

<1 EU/μg

UniProt-Hinterlegungsnummer

P04085

Lagertemp.

−20°C

Angaben zum Gen

human ... PDGFRA(5154)

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Allgemeine Beschreibung

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Biochem./physiol. Wirkung

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Sonstige Hinweise

Homodimer of the A chain of human PDGF.

Physikalische Form

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Hinweis zur Analyse

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Artikel

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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