Direkt zum Inhalt
Merck
Alle Fotos(2)

Dokumente

M7033

Sigma-Aldrich

Nω-Methyl-L-arginin -acetat (Salz)

≥98% (TLC), powder, nitric oxide synthase inhibitor

Synonym(e):

L-NMMA, N5-(Methylamidino)-L-ornithin -acetat (Salz), NG-Methyl-L-Arginin -acetat (Salz), NG-Monomethyl-L-arginin -acetat (Salz)

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)

About This Item

Empirische Formel (Hill-System):
C7H16N4O2 · C2H4O2
CAS-Nummer:
53308-83-1
Molekulargewicht:
248.28
Beilstein:
6674255
MDL-Nummer:
MFCD00069311
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24278043
NACRES:
NA.77

product name

Nω-Methyl-L-arginin -acetat (Salz), ≥98% (TLC)

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Löslichkeit

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

SMILES String

CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

InChIKey

IKPNWIGTWUZCKM-JEDNCBNOSA-N

Angaben zum Gen

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)
mouse ... Nos2(18126)
rat ... Nos1(24598) , Nos2(24599)

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Anwendung

NG-Methyl-L-arginine acetate salt has been used:
  • as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
  • as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
  • as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

Biochem./physiol. Wirkung

NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Leistungsmerkmale und Vorteile

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Safa Al Therwani et al.
BMC nephrology, 18(1), 86-86 (2017-03-16)
Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of
Immune parameters in the common octopus (Octopus vulgaris Cuvier, 1797) naturally infected by the gastrointestinal protozoan parasite Aggregata octopiana
Castellanos-Martinez S and Gestal C
Aquaculture (Amsterdam, Netherlands), 497, 487-493 (2018)
Nitric oxide induces epidermal stem cell de-adhesion by targeting integrin beta1 and Talin via the cGMP signalling pathway
Zhan R, et al.
Nitric Oxide, 78, 1-10 (2018)
NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase
Olken NM and Marletta MA
Biochemistry, 32(37), 9677-9685 (1993)
Jonna Idh et al.
PloS one, 12(7), e0181221-e0181221 (2017-07-14)
Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical
Alle zugehörigen Dokumente anzeigen

Artikel

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.