L2012
Lipopolysaccharide aus Salmonella enteritidis
purified by gel-filtration chromatography
Synonym(e):
LPS
Technischer Dienst
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Unterstützung erhaltenTechnischer Dienst
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Unterstützung erhaltenbiological source
Salmonella enterica (Serotype enteritidis)
Quality Level
form
lyophilized powder
purified by
gel-filtration chromatography
impurities
<1% Protein
color
white to faint yellow
solubility
water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
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Verwandte Kategorien
General description
This product is extracted from Salmonella enteritidis and purified by gel filtration. The source strain is ATCC 13076. Lipopolysaccharide from Salmonella enteritidis is mutagenic in murine spleen cells and causes a plaque-forming response in those cells.
Application
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4).
Biochem/physiol Actions
Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.
Preparation Note
The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.
Other Notes
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Laman K Mamedova et al.
The Journal of nutritional biochemistry, 24(8), 1499-1507 (2013-03-08)
Saturated free fatty acids (FFA) can activate inflammatory cascades including the toll-like receptor 4 (TLR4) pathway. TLR4 is expressed by hepatocytes and may help link FFA to altered hepatic gluconeogenesis in type 2 diabetes mellitus. This study examined the role
A Zarbock et al.
British journal of pharmacology, 155(3), 357-364 (2008-07-01)
Acute lung injury (ALI) remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of ALI. The main chemokine receptor on neutrophils is CXCR2, which regulates neutrophil recruitment and
Basilia Zingarelli et al.
Immunology, 124(1), 51-57 (2007-11-22)
Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Here
Jörg Reutershan et al.
European journal of immunology, 39(6), 1597-1607 (2009-06-06)
The Duffy antigen receptor for chemokines (DARC) has a high affinity for CC and CXC chemokines. However, it lacks the ability to induce cell responses that are typical for classical chemokine receptors. The role of DARC in inflammatory conditions remains
Graciliana Lopes et al.
PloS one, 7(2), e31145-e31145 (2012-02-10)
Bacterial and fungal infections and the emerging multidrug resistance are driving interest in fighting these microorganisms with natural products, which have generally been considered complementary to pharmacological therapies. Phlorotannins are polyphenols restricted to brown seaweeds, recognized for their biological capacity.
Artikel
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
Verwandter Inhalt
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L2012-10MG | 04061833272015 |
| L2012-25MG | 04061833289761 |
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