TS Answer: The content of Gramicidins A1, A2, B1, C1 and C2 in G5002 is lot-dependent & is ≥ 95.0 %. The content of Gramicidin A1 is also lot-dependent & is ≥ 60.0 %. Please refer to lot-specific CoA. The % contents of the other Gramicidins are not determined in-house. According to published literature citations, Gramicidin A is pore-forming.
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G5002
Gramicidin
from Bacillus aneurinolyticus (Bacillus brevis), powder or crystalline powder, antibiotic
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 37.20 |
500 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 68.10 |
1 g | Warenkorb auf Verfügbarkeit prüfen | CHF 109.00 |
5 g | Warenkorb auf Verfügbarkeit prüfen | CHF 429.00 CHF 364.65 |
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Unterstützung erhaltenProduktname
Gramicidin from Bacillus aneurinolyticus (Bacillus brevis), Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.
Quality Segment
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell membrane | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
[nH]1c2c(c(c1)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)C)CC(C)C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc7c8c([nH]c7)cccc8)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc5c6c([nH]c5)
InChI
1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83-,84+,85-/m0/s1
InChI key
ZWCXYZRRTRDGQE-SORVKSEFSA-N
General description
Chemical structure: peptide
Gramicidin A is a linear pentadecapeptide antibiotic produced by Bacillus brevis. The transmembrane protein contains a left-handed helix with alternating L and D residues.
Application
Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) has been used as a control to measure the rate of diffusion of protonated β-lactams through the lipid bilayer in liposome swelling assay. It has also been used as an analyte for the purpose of infrared laser desorption or ionization from silicon.
Biochem/physiol Actions
Linear polypeptide antibiotic mixture of gramicidin A, B, C, and D.
Linear polypeptide antibiotic, a mixture of gramicidin A, B, C, and D. Gramicidin D, a channel-forming ionophore that flip-flops slowly across the membrane is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.
Linear polypeptide antibiotic mixture of gramicidin A, B, C, and D. Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer.
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Dieser Artikel | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| mode of action cell membrane | interferes, enzyme | inhibits | mode of action cell membrane | interferes, enzyme | inhibits | mode of action cell membrane | interferes, enzyme | inhibits | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - |
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Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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I have a question about this product (gramicidin) - What is the composition/percentage of A, B, C, D in this Gramicidin mix? Which one has the pore-forming activity, A, B, C or D? Thanks!
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