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F8174
Follicle Stimulating Hormone from sheep pituitary
Synonym(e):
FSH
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General description
FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH (luteinizing hormone), hCG (human chorionic gonadotropin) and TSH (thyrotropin-releasing hormone), which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.[1]
Application
Follicle stimulating hormone from sheep pituitary has been used for-
- the in vitro maturation of bovine ovaries[2]
- the hormonal treatment of Sertoli cells[3]
- the intraperitoneal hormone treatment of male lizards[4]
- the intramuscular hormone treatment of American alligator (Alligator mississippiensis)[5]
- use in medium used for the maturation of bovine cumulus-oocyte complexes (COCs)[6]
Biochem/physiol Actions
FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis.[7][8] In Caucasian population, certain polymorphisms in FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS).[7]
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
Analysis Note
50 units per vial by the Steelman-Pohley assay using NIH-FSH-S1 reference standard.
Other Notes
Two-chain glycoprotein hormone
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Feng Wang et al.
Fertility and sterility, 101(2), 577-586 (2013-12-10)
To analyze the potential beneficial effects and mechanisms of action of resveratrol on the maturation of bovine oocytes that were incubated in different concentrations of resveratrol (0.1, 1.0, or 10.0 μM) as germinal vesicle-stage oocytes. In vitro prospective study. University
Levent Keskintepe et al.
Biology of reproduction, 67(2), 409-415 (2002-07-24)
Pronuclear formation, and the chromosomal constitution and developmental capacity of bovine zygotes formed by intracytoplasmic sperm injection with freeze-dried (lyophilized) spermatozoa were evaluated. Frozen-thawed spermatozoa were selected, freeze-dried, and stored at 4 degrees C until use. After 22-24 h of
Suzanne C Mills et al.
The American naturalist, 171(3), 339-357 (2008-01-19)
Sexual selection predicts that trade-offs maintain trait variation in alternative reproductive strategies. Experiments often focus on testosterone (T), but the gonadotropins follicle-stimulating hormone and luteinizing hormone may provide a clearer understanding of the pleiotropic relationships among traits. We assess the