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F0762
N-Formyl-Met-Leu-Phe-o-fluorobenzylamide
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Empirische Formel (Hill-System):
C28H37FN4O3S
CAS-Nummer:
Molekulargewicht:
528.68
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
form
solid
storage temp.
−20°C
SMILES string
CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NCc2ccccc2F
InChI
1S/C28H37FN4O4S/c1-19(2)15-24(32-27(36)23(31-18-34)13-14-38-3)28(37)33-25(16-20-9-5-4-6-10-20)26(35)30-17-21-11-7-8-12-22(21)29/h4-12,18-19,23-25H,13-17H2,1-3H3,(H,30,35)(H,31,34)(H,32,36)(H,33,37)
InChI key
LTOZIPKEOGLEJO-UHFFFAOYSA-N
Biochem/physiol Actions
N-Formyl-Met-Leu-Phe-o-fluorobenzylamide is a C-terminal blocked derivative of the chemotatic/chemoattractant tripeptide fMLF. N-Formyl-Met-Leu-Phe-o-fluorobenzylamide may be used to probe human formyl peptide receptors and fMLF functions.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Fujie Tanaka et al.
Bioorganic & medicinal chemistry letters, 17(7), 1943-1945 (2007-02-13)
Antibodies that selectively bind to N-formylmethionyl leucyl phenylalanine (fMLF, also known as fMLP) have been generated. These antibodies bound to fMLF with higher affinity than to non-formylated peptide MLF: the differences in the binding energies between fMLF and MLF were
Wulin Aerbajinai et al.
Journal of leukocyte biology, 90(3), 529-538 (2011-06-10)
Chemotaxis is fundamental to the directional migration of neutrophils toward endogenous and exogenous chemoattractants. Recent studies have demonstrated that ADF/cofilin superfamily members play important roles in reorganizing the actin cytoskeleton by disassembling actin filaments. GMFG, a novel ADF/cofilin superfamily protein
C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F0762-5MG | 04061832416274 |