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D4813
Dendrotoxin-K
≥98% (HPLC), potassium channels inhibitor, lyophilized powder
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 1 vial | Warenkorb auf Verfügbarkeit prüfen | CHF 356.00 |
Über diesen Artikel
Assay:
≥98% (HPLC)
Form:
lyophilized powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Dendrotoxin-K, ≥98% (HPLC), lyophilized powder
Quality Segment
assay
≥98% (HPLC)
form
lyophilized powder
mol wt
6,542 Da
storage temp.
−20°C
Application
Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells.[1] It has also been used as a selective blocker of Kv channels in mice.
Biochem/physiol Actions
Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.
Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.[2]
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Purified by a modification of the method of Schweitz.[3]
Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock
Other Notes
Isolated initially from Dendroaspis polylepis polylepis venom
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| mol wt 6,542 Da | mol wt 3921 Da | mol wt - | mol wt - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D4813-1VL | 04061832574301 |