D4010
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate
≥96% (HPLC), synthetic (organic), powder
Synonym(e):
2′-deoxy-, 5′-triphosphate sodium salt, Guanosine, dGTP sodium salt hydrate
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10 MG
CHF 229.00
100 MG
CHF 1’490.00
1 G
CHF 8’320.00
CHF 229.00
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Über diesen Artikel
Empirische Formel (Hill-System):
C10H16N5O13P3 · xNa+ · yH2O
CAS-Nummer:
Molekulargewicht:
507.18 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Storage temp.:
−20°C
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Unterstützung erhaltenProduktname
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate, ≥96% (HPLC)
biological source
synthetic (organic)
assay
≥96% (HPLC)
form
powder
shipped in
dry ice
storage temp.
−20°C
Quality Level
Verwandte Kategorien
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| assay ≥96% (HPLC) | assay ≥90% (HPLC) | assay ≥99% | assay ≥99% |
| form powder | form powder | form liquid | form liquid |
| shipped in dry ice | shipped in - | shipped in dry ice | shipped in dry ice |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Application
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:
- as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers[1]
- as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process[2]
- as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors[3]
Biochem/physiol Actions
Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Yogesh A Karpe et al.
PloS one, 6(7), e22336-e22336 (2011-08-04)
Chikungunya virus (CHIKV) is an insect borne virus (genus: Alphavirus) which causes acute febrile illness in humans followed by a prolonged arthralgic disease that affects the joints of the extremities. Re-emergence of the virus in the form of outbreaks in
Rajesh Kasiviswanathan et al.
The Journal of biological chemistry, 286(36), 31490-31500 (2011-07-23)
During DNA synthesis, DNA polymerases must select against ribonucleotides, present at much higher levels compared with deoxyribonucleotides. Most DNA polymerases are equipped to exclude ribonucleotides from their active site through a bulky side chain residue that can sterically block the
Yimon Aye et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9815-9820 (2011-06-02)
Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of α- and β-subunits that form active α(n)β(m) (n, m = 2 or 6) complexes. α binds NDP substrates (CDP, UDP, ADP, and GDP, C site)
Inchul Yang et al.
Analytical biochemistry, 335(1), 150-161 (2004-11-03)
A novel approach for quantitation of DNA (oligonucleotides) with an unprecedented accuracy of approximately 1% is reported. Quantitation of DNA is commonly performed by measuring UV absorption or fluorescence from dyes intercalated into DNA. Both methods need accurate quantitation standards
Si Min Zhang et al.
Cell chemical biology, 28(12), 1693-1702 (2021-07-01)
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating
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