D1771

5′-Desoxyadenosin

≥98% (TLC), synthetic (organic), powder

• Synonym(e): 5′-dAdo
• Empirische Formel (Hill-System): C₁₀H₁₃N₅O₃
• CAS-Nummer: 4754-39-6
• Molekulargewicht: 251.24
• UNSPSC Code: 41106305
• PubChem Substance ID: 24893539
• NACRES: NA.51
• MDL number: MFCD00056003
• Assay: ≥98% (TLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: hot water: 19.60-20.40 mg/mL, clear, colorless
• Storage temp.: 2-8°C

Eigenschaften

• Produktname: 5′-Desoxyadenosin, methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase substrate
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: hot water: 19.60-20.40 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C10H13N5O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI key: XGYIMTFOTBMPFP-KQYNXXCUSA-N

Beschreibung

Application

5′-Deoxyadenosine has been used:

• as a standard in mass spectroscopy[1]
• as an inhibitor for screening thymidine phosphorylase activity
• as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay

Biochem/physiol Actions

5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes.[2] 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes.[2] It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)