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D103
(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride
solid
Synonym(e):
DCMB, LY-78335
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Empirische Formel (Hill-System):
C8H9Cl2N · HCl
CAS-Nummer:
Molekulargewicht:
226.53
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
form
solid
color
white
solubility
H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.), ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)
SMILES string
Cl[H].CC(N)c1cccc(Cl)c1Cl
Gene Information
human ... PNMT(5409)
Biochem/physiol Actions
PNMT inhibitor.
Lagerklasse
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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G Engberg et al.
Brain research, 223(1), 49-58 (1981-10-26)
The functional significance of the morphologically identified adrenaline (A)-mediated input to the noradrenergic nucleus locus coeruleus (LC) was pharmacologically analyzed. By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F
R W Fuller
Annual review of pharmacology and toxicology, 22, 31-55 (1982-01-01)
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord. These neurons can be affected pharmacologically by various kinds
T A Glauser et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 657-669 (1993-06-01)
1. Thiol methyltransferase (TMT) is a microsomal enzyme catalyzing the S-methylation of aliphatic sulphydryl drugs and xenobiotics. Studies of the functional significance of S-methylation catalysed by TMT have been hampered by lack of a potent, relatively specific, non-toxic inhibitor of