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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Synonym(e):

DCMB, LY-78335

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About This Item

Empirische Formel (Hill-System):
C8H9Cl2N · HCl
CAS-Nummer:
39226-94-3
Molekulargewicht:
226.53
MDL-Nummer:
MFCD00055225
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278157

Form

solid

Farbe

white

Löslichkeit

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES String

Cl[H].CC(N)c1cccc(Cl)c1Cl

Angaben zum Gen

human ... PNMT(5409)

Biochem./physiol. Wirkung

PNMT inhibitor.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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T A Glauser et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 657-669 (1993-06-01)
1. Thiol methyltransferase (TMT) is a microsomal enzyme catalyzing the S-methylation of aliphatic sulphydryl drugs and xenobiotics. Studies of the functional significance of S-methylation catalysed by TMT have been hampered by lack of a potent, relatively specific, non-toxic inhibitor of
G Engberg et al.
Brain research, 223(1), 49-58 (1981-10-26)
The functional significance of the morphologically identified adrenaline (A)-mediated input to the noradrenergic nucleus locus coeruleus (LC) was pharmacologically analyzed. By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F
R W Fuller
Annual review of pharmacology and toxicology, 22, 31-55 (1982-01-01)
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord. These neurons can be affected pharmacologically by various kinds
N Y Liang et al.
The Journal of pharmacology and experimental therapeutics, 223(2), 382-387 (1982-11-01)
Intraperitoneal injections of the phenylethanolamine N-methyltransferase inhibitors 2-cyclohexyl-2-hydroxyethylamine, 1-aminomethylcycloundecanol, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline and 2,3-dichloro-alpha-methylbenzylamine all lowered blood pressures in spontaneously hypertensive rats. The drugs did not affect the blood pressures of age-paired normotensive Wistar Kyoto rats or did the drugs alter the
E Spinedi et al.
Endocrinology, 122(5), 1977-1983 (1988-05-01)
Epinephrine (EPI) has been described to stimulate the hypothalamic-pituitary-adrenal axis. However, whether central EPI neuronal systems play a major physiological role in the regulation of ACTH secretion and whether that role is primarily stimulatory or inhibitory in nature is still
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