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D054
R(+)-SCH-23390 -hydrochlorid
≥98% (HPLC), dopamine receptor antagonist, solid
Synonym(e):
R(+)-7-Chlor-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin -hydrochlorid
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 104.00 | |
| 10 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 177.00 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 430.00 | |
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 1’420.00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C17H18ClNO · HCl
CAS-Nummer:
Molekulargewicht:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Technischer Dienst
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Unterstützung erhaltenProduktname
R(+)-SCH-23390 -hydrochlorid, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D +32.1°, c = 1 in DMF(lit.)
storage condition
desiccated, protect from light
color
white
solubility
H2O: >5 mg/mL
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Gene Information
human ... DRD1(1812)
Application
R(+)-SCH-23390-Hydrochlorid wurde verwendet:
- für die intraperitoneale Injektion in Laborratten zur Untersuchung der Rolle des D1-Rezeptors bei der Sensibilisierung
- als ein D1-Rezeptor-selektiver Antagonist für intrakraniale Arzneistoffinfusionen
- als ein Antagonist des D1-Rezeptors zur Untersuchung seiner Wirkung auf die Lernfähigkeit in Fischen
Biochem/physiol Actions
R(+)-SCH-23390-Hydrochlorid ist ein selektiver D1-Dopaminrezeptorantagonist. Es hat eine größere Bindungsfähigkeit an 5-Hydroxytryptamin-2 (5-HT2) und 5-HT1C-Serotoninrezeptor-Subtypen in-vitro. Die Halbwertszeit von R(+)-SCH-23390 beträgt 25 Minuten nach der Verabreichung. Es bekannt, dass es eine anti-stereotypische und eine kataleptogene Wirkung hat. Es hat auch eine hemmende Wirkung auf die motorische Aktivität.
Features and Benefits
Diese Verbindung ist auf den Seiten Dopamine Receptors und Potassium Channels im „Handbook of Receptor Classification and Signal Transduction“ aufgeführt. Um andere Seiten dieses Handbuchs anzuzeigen, klicken Sie bitte hier.
Legal Information
Wird mit der Genehmigung von Schering-Plough verkauft.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form solid | form crystalline | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage condition desiccated, protect from light | storage condition desiccated, protect from light | storage condition desiccated | storage condition - |
| solubility H2O: >5 mg/mL | solubility H2O: >5 mg/mL, aqueous base: soluble (unstable) | solubility H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL | solubility H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble |
| color white | color white | color white to light tan | color tan |
Lagerklasse
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
A Sidhu et al.
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D054-25MG | 04061833557815 |
| D054-5MG | 04061833557822 |
| D054-10MG | 04061833557808 |
| D054-100MG | 04061832090108 |
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What is the Department of Transportation shipping information for this product?
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How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.
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Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?
1 answer-
The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?
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Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.
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Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?
1 answer-
Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.
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What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
The melting point is 247-248°C.
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