C271

CX546

≥98% (HPLC), solid

• Synonym(e): 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
• Empirische Formel (Hill-System): C₁₄H₁₇NO₃
• CAS-Nummer: 215923-54-9
• Molekulargewicht: 247.29
• NACRES: NA.77
• PubChem Substance ID: 24277960
• UNSPSC Code: 12352200
• MDL number: MFCD01860868
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(N1CCCCC1)c2ccc3OCCOc3c2
• InChI: 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
• InChI key: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Beschreibung

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.[1]

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Biochem/physiol Actions

Positive AMPA glutamate receptor modulator.

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Disclaimer

Photosensitive

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)