B9935

BMS-345541

≥98% (HPLC), powder

• Synonym(e): N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
• Empirische Formel (Hill-System): C₁₄H₁₇N₅ · HCl
• CAS-Nummer: 547757-23-3
• Molekulargewicht: 291.78
• NACRES: NA.77
• PubChem Substance ID: 24724429
• UNSPSC Code: 12352200
• MDL number: MFCD07784499
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1
• InChI: 1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
• InChI key: MIDKPVLYXNLFGZ-UHFFFAOYSA-N

Beschreibung

Application

BMS-345541 has been used:

• as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells[1]
• as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts[2]
• as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells[3]

Biochem/physiol Actions

BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.

BMS-345541 possesses anti-inflammatory properties.[4] It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines.[5] BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.[2]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)