B2432
8-Bromoadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer
≥98% (HPLC), solid
Synonym(e):
Rp-8-Br-cAMPS
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C10H10BrN5O5PSNa
Molekulargewicht:
446.15
UNSPSC-Code:
41106305
NACRES:
NA.77
Empfohlene Produkte
Qualitätsniveau
Assay
≥98% (HPLC)
Form
solid
Verpackung
vial of 5 μmol
Löslichkeit
water: soluble
Lagertemp.
−20°C
Biochem./physiol. Wirkung
Competitive inhibitor of cyclic AMP-dependent protein kinase A (PKA) type I and II. Membrane-permeable analog of the cAMP inhibitor Rp-cAMPS (Prod. No. A-165).
Leistungsmerkmale und Vorteile
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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B T Gjertsen et al.
The Journal of biological chemistry, 270(35), 20599-20607 (1995-09-01)
Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact cells. These
Angeline Eymery et al.
Development (Cambridge, England), 143(15), 2767-2779 (2016-06-19)
Oocytes develop the competence for meiosis and early embryogenesis during their growth. Setdb1 is a histone H3 lysine 9 (H3K9) methyltransferase required for post-implantation development and has been implicated in the transcriptional silencing of genes and endogenous retroviral elements (ERVs).
Ho Lin et al.
Endocrinology, 150(1), 396-403 (2008-08-30)
The roles of cyclin-dependent kinase 5 (Cdk5) in central nervous system and neurodegenerative diseases have been intensely investigated in recent decades. Because protein expressions of Cdk5 and its regulator, p35, have been identified in Leydig cells, it is informative to
Mei-Chih Chen et al.
American journal of physiology. Cell physiology, 299(2), C516-C527 (2010-05-14)
The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-dependent kinase
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