A9855

3-Acetyl-11-keto-BETA-boswellic acid

from Boswellia serrata

• Synonym(e): AKBA
• Empirische Formel (Hill-System): C₃₂H₄₈O₅
• CAS-Nummer: 67416-61-9
• Molekulargewicht: 512.72
• UNSPSC-Code: 12352106
• NACRES: NA.25

Eigenschaften

• Biologische Quelle: Boswellia serrata
• Form: powder
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: −20°C
• InChI: 1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
• InChIKey: HMMGKOVEOFBCAU-BCDBGHSCSA-N

Beschreibung

Allgemeine Beschreibung

Acetyl-11-keto-β-boswellic acid (AKBA) is extracted from the resin of Boswellia serrata.

Anwendung

3-Acetyl-11-keto-β-boswellic acid (AKBA) has been used:

• to test its effects as an anti-proliferating agent on hepatic stellate cells (HSCs) proliferation and synergism in combination with imatinib in in vitro models
• to study its anti-osteoporotic activity on ovariectomy-induced osteoporosis in female Sprague Dawley rats
• in a comparative study with aspirin to test its effects as an anti-inflammatory drug to prevent intestinal adenomatous polyposis in APC^Min/+ mice

Biochem./physiol. Wirkung

Acetyl-11-keto-β-boswellic acid (AKBA) displays antibacterial and anti-biofilm activities against Staphylococcus epidermidis and S. aureus, respectively. It is an activator of nuclear factor erythroid-2-related factor 2 (Nrf2) and exerts neuroprotective properties against ischemic injury in both in vitro and in vivo studies.

Acetyl-11-keto-beta-boswellic acid is a pentacyclic triterpene that inhibits 5-lipoxygenase in a selective, enzyme-directed, nonredox, and noncompetitive manner. It has also been shown to inhibit topoisomerase I and NF-κB signaling.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable