Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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A0580
Arachidonylethanolamide
≥97.0% (TLC), oil
Synonym(e):
Anandamide (20:4, n-6), AEA, Anandamide, Arachidonic acid N-(hydroxyethyl)amide
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 114.00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 441.00 CHF 330.75 |
Über diesen Artikel
Empirische Formel (Hill-System):
C22H37NO2
CAS-Nummer:
Molekulargewicht:
347.53
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥97.0% (TLC)
form
oil
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
colorless to light yellow
solubility
ethanol: soluble
density
0.92 g/mL at 25 °C (lit.)
lipid type
omega FAs
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCCO
InChI
1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
InChI key
LGEQQWMQCRIYKG-DOFZRALJSA-N
Gene Information
rat ... Cnr1(25248)
Application
- Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery: Investigates Arachidonylethanolamide′s interactions with opioid systems, providing insights that could lead to better management of postoperative pain and opioid use (Stone et al., 2024).
Biochem/physiol Actions
An arachidonic acid derivative that is an endogenous ligand for the CB cannabinoid receptor and for the VR1 vanilloid receptor. Inhibits calcium currents in neuroblastomas and neurons. Activates the MAP kinase signaling pathway. Inhibits proliferation and induces apoptosis of lymphocytes and human breast cancer cells.
Disclaimer
Protect from light and moisture.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥97.0% (TLC) | assay ≥99% (TLC and GC) | assay ~98% (TLC) | assay >99% (TLC) |
| form oil | form oil | form powder | form liquid |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in dry ice |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. −70°C |
| solubility ethanol: soluble | solubility ethanol: 5 mg/mL | solubility chloroform: 20 mg/mL, clear, colorless | solubility - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level - |
Lagerklasse
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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What is the Department of Transportation shipping information for this product?
1 answer-
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How to dissolve Product A0580, Arachidonylethanolamide?
1 answer-
Arachidonylethanolamide (also known as anandamide) is soluble in ethanol (100 mM) and in DMSO (10 mg/ml) and is poorly soluble in water. Hydroxypropyl -β cyclodextran has been reported to increase the aqueous solubility and stability of anandamide. Jarho, P. et al., Life Sciences, 58, 181 (1996).
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Is Product A0580, Arachidonylethanolamide, a solution?
1 answer-
No, the product is naturally an oily liquid. An approximate molarity for the liquid is 2.6 M (based on a molecular weight of 347.5 g/mole and an approximate density of 0.92 g/mL at 25°C).
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Can solutions of Product A0580, Arachidonylethanolamide, be stored?
1 answer-
Sigma has not evaluated the solution stability of this product. Solutions in ethanol, stored under argon at -20°C, have been reported (see Schuel, H.. et al., Proc. Nat. Acad. Sci., USA, 91, 7678-7682 (1994) and Spivak, C.E., Mol. Pharmacol., 72, 1024-1032 (2007)). If solutions are to be stored, it would be best to use a degassed solvent or solvent purged with argon. Store solutions under argon in the freezer, at -20°C or colder. Store solutions protected from light and oxygen to prevent the oxidation of the double bonds.
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