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79286
Phalloidin-Atto 700
suitable for fluorescence, ≥90% (HPLC)
Synonym(e):
Atto 700–Phalloidin
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Über diesen Artikel
NACRES:
NA.32
UNSPSC Code:
12352116
assay
≥90% (HPLC)
form
powder
manufacturer/tradename
ATTO-TEC GmbH
transmittance
254 nm, 700 nm
fluorescence
λex 700 nm; λem 719 nm in 0.1 M phosphate pH 7.0
λ
in methanol
suitability
suitable for fluorescence
storage temp.
−20°C
General description
Atto 700 belongs to a new generation of fluorescent labels. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are strong absorption, high fluorescence quantum yield, excellent thermal and photo-stability, very good water solubility and very little triplet formation. Atto 700 is a zwitterionic dye with a net electrical charge of zero. The fluorescence is efficiently quenched by electron donors like guanine, tryptophan, etc
Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
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Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
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Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.
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Dieser Artikel | |||
|---|---|---|---|
| suitability suitable for fluorescence | suitability suitable for fluorescence | suitability suitable for fluorescence | suitability suitable for fluorescence |
| fluorescence λex 700 nm; λem 719 nm in 0.1 M phosphate pH 7.0 | fluorescence λex 663 nm; λem 684 nm in 0.1 M phosphate pH 7.0 | fluorescence - | fluorescence λex 750 nm; λem 764 nm in 0.1 M phosphate pH 7.0 |
| form powder | form solid | form - | form powder |
| assay ≥90% (HPLC) | assay ≥90.0% (sum of isomers, HPLC) | assay ≥90% (HPLC) | assay ≥90.0% (HPLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| transmittance 254 nm, 700 nm | transmittance 254 nm, 655 nm | transmittance - | transmittance 254 nm, 740 nm |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
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Verwandter Inhalt
David Ochoa et al.
Molecular systems biology, 12(12), 888-888 (2016-12-03)
The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision-making has been limited by the small number of simultaneously monitored phospho-regulatory events. Here, we
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 79286-10NMOL | 04061833248638 |