Fortfahren mit
70485
Naphthol-AS-E-Phosphat
suitable for histology
Synonym(e):
KG-501
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 250 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 85.10 |
Über diesen Artikel
Empirische Formel (Hill-System):
C17H13ClNO5P
CAS-Nummer:
Molekulargewicht:
377.72
UNSPSC Code:
12352204
NACRES:
NA.83
PubChem Substance ID:
EC Number:
242-106-1
Beilstein/REAXYS Number:
6664478
MDL number:
CHF 85.10
Warenkorb auf Verfügbarkeit prüfen
Technischer Dienst
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Unterstützung erhaltenassay
≥80% (HPLC)
Quality Level
form
powder
application(s)
histology
storage temp.
2-8°C
SMILES string
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI key
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Application
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biochem/physiol Actions
Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.
Other Notes
Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction[1].
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥80% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| form powder | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| application(s) histology | application(s) - | application(s) - | application(s) - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 70485-250MG | 04061833054550 |