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53340

L-Histidin -dihydrochlorid

≥99.0% (AT)

Synonym(e):

L-Histidine hydrochloride (1:2)

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Über diesen Artikel

Empirische Formel (Hill-System):
C6H9N3O2 · 2HCl
CAS-Nummer:
Molekulargewicht:
228.08
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
227-890-5
MDL number:
Beilstein/REAXYS Number:
6119230
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Produktname

L-Histidin -dihydrochlorid, ≥99.0% (AT)

Quality Level

assay

≥99.0% (AT)

form

powder or crystals

optical activity

[α]20/D +6.5±1°, c = 8% in H2O

ign. residue

≤0.1% (as SO4)

color

white

mp

240-245 °C (dec.)

solubility

H2O: soluble, saline: soluble

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

As: ≤0.1 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, NH4+: ≤500 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

Cl.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.2ClH/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);2*1H/t5-;;/m0../s1

InChI key

XEJCDBUNISUVGZ-XRIGFGBMSA-N

Biochem/physiol Actions

L-Histidine is a natural proteinogenic α amino acid useful as a cell growth supplement that support protein and peptide biosynthesis. L-Histidine is studied in a wide range of applications that involve imidazole chemistry and biochemisty.
L-Histidine is a positively charged imidazole-side chain containing α amino acid. It is metabolized to histamine and is a precursor of the dipeptide carnosine. As one of the 22 proteinogenic amino acids L-His is incorporated into proteins by translation processes in vitro. L-Histidine is an essential amino acid added to cell culture media.

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Dieser Artikel
H1540330120M9005
form

powder or crystals

form

-

form

powder or crystals

form

powder

assay

≥99.0% (AT)

assay

97%

assay

≥99.0% (RT)

assay

≥98% (TLC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

color

white

color

white

color

white

color

white to off-white

mp

240-245 °C (dec.)

mp

207 °C (dec.) (lit.)

mp

174.1-174.7 °C

mp

254 °C

optical activity

[α]20/D +6.5±1°, c = 8% in H2O

optical activity

[α]20/D +9.0°, c = 2 in H2O

optical activity

[α]20/D +6.4±0.3°, c = 5% in 5 M HCl

optical activity

-


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Azzurra Stefanucci et al.
International journal of molecular sciences, 12(5), 2853-2890 (2011-06-21)
A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and selectivity as with
Jorge A Vila et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(14), 5602-5607 (2011-03-23)
A method is proposed to determine the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of pH, provided that the observed and chemical shifts and the protein structure, or the fraction of
Amir Abbas Farshid et al.
Drug and chemical toxicology, 38(4), 436-441 (2014-11-28)
In this study, the effect of separate and combined intraperitoneal (i.p.) injections of histidine and n-acetylcysteine were investigated on experimental damage induced by doxorubicin (DOX) in sciatic nerve of rats. DOX was i.p. injected at a dose of 4 mg/kg once



Global Trade Item Number

SKUGTIN
493155-1G04061826664407
53340-50G04061832559193
53340-10G04061832719320

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