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04555

Trypanothion -trifluoracetat (Salz)

≥98% (HPLC)

Synonym(e):

N1,N8-Bis-(glutathionyl)-spermidin-disulfid

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Über diesen Artikel

Empirische Formel (Hill-System):
C27H47N9O10S2 · xC2HF3O2
CAS-Nummer:
Molekulargewicht:
721.85 (free base basis)
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3645155
Assay:
≥98% (HPLC)
Form:
powder or crystals


assay

≥98% (HPLC)

form

powder or crystals

solubility

water: soluble 1 g/L

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.N[C@@H](CCC(=O)N[C@H]1CSSCC(NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(=O)NCCCNCCCCNC(=O)CNC1=O)C(O)=O

InChI

1S/C27H47N9O10S2.C2HF3O2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41;3-2(4,5)1(6)7/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46);(H,6,7)/t16-,17-,18-,19?;/m0./s1

InChI key

BLTBWJNAZIKNTL-QZBRSAASSA-N

Biochem/physiol Actions

Metabolite in the glutathione metabolism. A novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids[1].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.


Lagerklasse

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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A H Fairlamb et al.
Science (New York, N.Y.), 227(4693), 1485-1487 (1985-03-22)
Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for
C Dumas et al.
The EMBO journal, 16(10), 2590-2598 (1997-05-15)
Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major thiol. Trypanothione reductase (TR), the enzyme responsible for maintaining trypanothione in its reduced form, is thought to be central to the redox defence systems of trypanosomatids. To investigate
R Mukhopadhyay et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(19), 10383-10387 (1996-09-17)
Leishmania resistant to arsenicals and antimonials extrude arsenite. Previous results of arsenite uptake into plasma membrane-enriched vesicles suggested that the transported species is a thiol adduct of arsenite. In this paper, we demonstrate that promastigotes of arsenite-resistant Leishmania tarentolae have



Global Trade Item Number

SKUGTIN
268992-5G04061826134894
268992-25G04061837580949
04555-1MG04061838633439
04555-5MG04061831579697

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