The maximum temperature that this resin can withstand has not been determined. Upon reviewing available literature, one citation reports usage of Wang resin at 40–50°C. Please see the link below to review this publication:
https://www.sciencedirect.com/topics/chemistry/wang-resin
8.55117
Hydroxylamine Wang resin
Novabiochem®
Synonym(e):
Amino-oxy Wang resin
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 g | Warenkorb auf Verfügbarkeit prüfen | CHF 169.00 | |
| 25 g | Warenkorb auf Verfügbarkeit prüfen | CHF 670.00 | |
| 100 g | Warenkorb auf Verfügbarkeit prüfen | CHF 2’540.00 |
Über diesen Artikel
NACRES:
NA.22
UNSPSC Code:
12352116
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenQuality Level
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
General description
An excellent support for the preparation of peptide hydroxamic acids [1] by Fmoc SPPS. Acylation of the resin has been carried out using TBTU/DIPEA activation [1]. Alkylation of the resin-bound nitrogen has been effected using TMOF/DCE/AcOH for imine formation, followed by reduction with BH3-pyridine [2], by base-mediated alkylation of the N-Boc-protected hydroxylamine, followed by Boc removal with 20% TFA in DCM [3], or by Michael-addition [4]. Cleavage of hydroxamates from the resin has been effected with TFA/DCM/water (70:28:2) [1] or TFA/DCM (1:1) [2]. Hydroxylamine Wang resin has also been utilized to prepare tertiary amines by base-mediated elimination of the quaternized polymer-bound hydroxylamine [3, 5].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Other Notes
Replaces: 01-64-0454
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis |
| product line Novabiochem® | product line Novabiochem® | product line - | product line Novabiochem® |
| Quality Level 200 | Quality Level 400 | Quality Level 100 | Quality Level 200 |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. - | storage temp. 2-30°C |
| form beads | form beads | form solid | form beads |
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 8551170005 | 04027269114619 |
| 8551170025 | 04027269114626 |
| 8551170100 | 04027269114633 |
-
What is the maximum temperature that this resin can withstand?
1 answer-
Helpful?
-
-
Does this Wang resin have a Fmoc group on it? Do I need to remove it when I first use it? Thanks so much!
1 answer-
This resin doesn't contain a Fmoc group but it can be added. Please refer to the following article, https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/peptide-synthesis/peptide-resin-loading.
Helpful?
-