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70990

α-Cyano-4-hydroxyzimtsäure

suitable for matrix substance for MALDI-MS, ≥99.0% (HPLC)

Synonym(e):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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PackungsgrößeSKUVerfügbarkeitPreis
250 mg
Warenkorb auf Verfügbarkeit prüfen
€ 38,80
1 g
Warenkorb auf Verfügbarkeit prüfen
€ 101,00

Über diesen Artikel

Lineare Formel:
HOC6H4CH=C(CN)CO2H
CAS-Nummer:
Molekulargewicht:
189.17
UNSPSC Code:
41115710
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Assay:
≥99.0% (HPLC)
Form:
solid

€ 38,80


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Quality Segment

assay

≥99.0% (HPLC)

form

solid

analyte chemical class(es)

glycans, peptides, proteins

technique(s)

MALDI-MS: suitable

mp

245-250 °C

solubility

methanol: 10 mg/mL, clear

cation traces

Ba: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, K: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤10 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

absorption

≥2000 at 337 nm (mol. absorption)

suitability

suitable for matrix substance for MALDI-MS

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

General description

α-Cyano-4-hydroxyzimtsäure (α-CHCA) wird häufig als Matrix verwendet, um die Ionisierung von Peptiden und Proteinen in einer Matrix-assistierten Laser-Desorption-Ionisierung (MALDI) mit kombiniertem Flugzeitanalysen(TOF)-Massenspektrometer (TOF, Time of Flight) zu ermöglichen.[1]

Application

α-CHCA wird als Matrix für einen verbesserten Nachweis des Verdaus von schwachen Proteinkonzentrationen in MALDI-TOF verwendet.[1]

Other Notes

Matrix substoncitatioance used in MALDI-MS (matrix-assisted laser desorption ionization MS) peptide analysis in proteomics.

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Dieser Artikel
39468C8982145505
assay

≥99.0% (HPLC)

assay

-

assay

-

assay

97%

form

solid

form

solid

form

powder

form

powder

technique(s)

MALDI-MS: suitable

technique(s)

MALDI-MS: suitable

technique(s)

-

technique(s)

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

methanol: 10 mg/mL, clear

solubility

methanol: 10 mg/mL, clear

solubility

-

solubility

methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow

analyte chemical class(es)

glycans, peptides, proteins

analyte chemical class(es)

glycans, peptides, proteins

analyte chemical class(es)

glycans, peptides, proteins

analyte chemical class(es)

-


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1B

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Verwandter Inhalt

Entdecken Sie unsere große Auswahl an Produkten für die Analyse der intakten Masse monoklonaler Antikörper, darunter Größenausschlusssäulen (SEC), Ionenaustauschsäulen, Umkehrphasensäulen, HPLC-Puffer, MALDI-Matrizen und -Standards, hochreine Lösungsmittel, Reagenzien, Werkzeuge für die Vorbereitung von Proteinproben und zertifizierte Referenzmaterialien.

Discover our wide variety of products for intact mass analysis of monoclonal antibodies, including size-exclusion columns (SEC), ion exchange columns, reverse-phase columns, HPLC buffers, MALDI matrices and standards, high-purity solvents, reagents, tools for protein sample preparation, and certified reference materials.






Global Trade Item Number

SKUGTIN
70990-250MG-F04061832843513
70990-1G-F04061832843384

Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

      Helpful?

  4. What is the shelf life of Product 70990, α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. This product does not have an Expiration or Recommended Re-Test date established for it.  As with all Sigma-Aldrich products, it is guaranteed up to a year from date of shipment.

      Helpful?

  5. What is the appearance of Product 70990, α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. Catalog number 70990 is a powder, and has an appearance specification of faintly yellow to yellow in color.

      Helpful?

  6. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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