This product has not been tested for solubility in DMSO. However, product 612030 is a Nicotine solution prepared at 2 mg/mL in DMSO. In addition, external sources indicate that this material is soluble up to 30 mg/mL in DMSO. Other solvents include Methanol, Ethanol, Dimethylformamide, and Chloroform.
Fortfahren mit
N3876
(−)-Nikotin
≥99% (GC), Prototype nicotinic acetylcholine receptor agonist, liquid
Synonym(e):
(−)-1-Methyl-2-(3-pyridyl)pyrrolidin, (S)-3-(1-Methyl-2-pyrrolidinyl)pyridin, L-(−)-3-(N-Methyl)-α-pyrrolidyl)-pyridin
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mL | Warenkorb auf Verfügbarkeit prüfen | € 82,50 |
25 mL | Warenkorb auf Verfügbarkeit prüfen | € 311,00 |
100 mL | Warenkorb auf Verfügbarkeit prüfen | € 313,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C10H14N2
CAS-Nummer:
Molekulargewicht:
162.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
200-193-3
MDL number:
Beilstein/REAXYS Number:
82109
Assay:
≥99% (GC)
Form:
liquid
Technischer Dienst
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Unterstützung erhaltenProduktname
(−)-Nikotin, ≥99% (GC), liquid
Quality Segment
assay
≥99% (GC)
form
liquid
optical activity
[α]20/D −169°(lit.)
color
yellow
refractive index
n20/D 1.5265 (lit.)
solubility
ethanol: 50 mg/mL
density
1.010 g/mL at 20 °C (lit.)
SMILES string
CN1CCC[C@H]1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChI key
SNICXCGAKADSCV-JTQLQIEISA-N
Gene Information
human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
mouse ... Chrna7(11441), Chrnb1(11443)
rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
General description
Nikotin ist das in den Blättern der Nicotiana-Spezies am häufigsten vorkommende Alkaloid. Es ist ein wichtiger toxischer Wirkstoff.
Application
(-)-Nikotin wird verwendet:
- zur Stimulierung von Neutrophilen im extrazellulären DNA-Fluoreszenztest und bei der Immunfärbung von Neutrophilen
- zur Untersuchung der Auswirkungen der chronischen Nikotinexposition von Neugeborenen auf die Nikotin-Acetylcholinrezeptor(nAChR)-Bindung, den Zelltod und die Morphologie im Hippocampus und Kleinhirn
- in einer In-vitro-Studie zur Bewertung der Wirkung einer Wurzelexposition gegenüber Nikotin oder Cotinin auf die Morphologie und Dichte von Fibroblasten
Biochem/physiol Actions
Prototyp Nikotin-Acetylcholin-Rezeptor-Agonist; natürlich vorkommendes Isomer.
Nikotin bindet an nikotinische Acetylcholinrezeptoren und zeigt sowohl neuroprotektive als auch neurotoxische Wirkungen auf das sich entwickelnde Gehirn. Es wird mit der Entwicklung von Lungenkrebs in Verbindung gebracht und verringert die Wirksamkeit von Chemotherapeutika. Darüber hinaus kann Nikotin die phagozytäre Wirtsabwehr beeinträchtigen und zu vermehrten, mit reaktiven Sauerstoffspezies (ROS) verbundenen Verletzungen führen. Es stoppt zudem die Deaktivierung der Akt/Proteinkinase B (PKB) und verringert den spontanen Tod von Neutrophilen. Nikotin wird zur Behandlung von Alzheimer und Parkinson eingesetzt.
Preparation Note
Dieses Produkt sollte in reinem Ethanol (200 Proof) aufgelöst werden.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥99% (GC) | assay - | assay ≥98% (TLC) | assay ≥95% (TLC) |
| form liquid | form - | form liquid | form liquid |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| solubility ethanol: 50 mg/mL | solubility - | solubility H2O: 20 mg/mL | solubility - |
| color yellow | color - | color yellow | color dark brown |
| density 1.010 g/mL at 20 °C (lit.) | density 1.010 g/mL at 20 °C (lit.) | density - | density - |
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signalword
Danger
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
213.8 °F - closed cup
flash_point_c
101 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
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Is that product soluble in DMSO?
1 answer-
Helpful?
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Is product N3876 (-)-Nicotine considered freebase nicotine or a nicotine salt dissolved in a carrier liquid
1 answer-
This product is nicotine free base and is provided in the form of a neat or pure liquid.
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Hi , How i want to measure the purity level of nicotine? Can refractive index or polarimeter use to measure level of impurity?
1 answer-
The measurement of purity in nicotine can be assessed using various analytical techniques. Refractive index and polarimetry are among the methods that can provide useful information. However, it's important to note that these techniques may not directly measure specific impurities but can be indicative of changes in the overall composition or characteristics of a substance. The purity of this product is determined by GC. Gas Chromatography (GC) is a widely used and effective method for assessing the purity of nicotine and detecting impurities. GC separates and analyzes components based on their volatility and interaction with a stationary phase.
Please access a Certificate of Analysis in the DOCUMENTATION section for reference:
https://www.sigmaaldrich.com/product/sigma/n3876#product-documentationHelpful?
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Hello, I would like to know the concentration of the nicotine in this liquid solution.
1 answer-
This product is a neat or pure liquid. Based on the density of 1.02 g/mL and the molecular weight of 162.2 g/mole, the calculated molar concentration is 6.3 M.
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How long is the nicotine stable if stored at room temperature? How long is it stable after being dssiolved and how should the solution be stored?
1 answer-
This compound is stored at room temperature, but is extremely sensitive to light, moisture, and oxygen. The product is a neat liquid and packaged in amber glass under argon to preserve stability. In the unopened container, the product is stable at least until the recommended retest date reported on the lot specific Certificate of Analysis. This date is typically 3 years from the quality release date. Factors such as light, humidity, and exposure to air will limit the shelf life after opening, It is recommended to prepare solutions fresh. The vial head space should be cleared with argon or nitrogen prior to closing. Increased darkening of the material is an indication of product degradation. Please see the link below to review a sample Certificate of Analysis:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/N3876-BULKBCCK8089.pdfHelpful?
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what % of ethanol should be used to be solublized?
1 answer-
This product should be dissolved in 200-proof, pure ethanol.
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What is the molarity of Product N3876, (-)-Nicotine?
1 answer-
The molarity of (-)-Nicotine is 6.23 M based on a 100% pure compound with a density at 20 °C equal to 1.010 g/mL. If you multiply this density by 1000, you obtain g/L. If you divide g/L by the molecular weight of (-)-Nicotine which is 162.2 g/mole, you get moles per L which is molarity. [1.010 x 1000]/162.2 = 6.23 M.
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Where should Product N3876, (-)-Nicotine, be stored and what sensitivities does it have?
1 answer-
For long-term storage, this product can be stored at room temperature. This compound is very hygroscopic and can darken in color on exposure to air and light.
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How can Product N3876, (-)-Nicotine, be solublized?
1 answer-
Product N3876, (-)-Nicotine, is soluble in ethanol. It is only miscible in water. We would recommend to solublized the product in ethanol to make a 1000x stock solution. This can then be diluted 1:1000 into aqueous buffer for use.
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What is the difference between Nicotine, Products N3876 and N0267?
1 answer-
Prod. No. N3876 is the naturally occurring (-) isomer while Prod. No. N0267 is a mixture of the (+) and (-) isomers.
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