In many instances, the salt form of a compound tends to be more stable that the free base form. However, side by side studies comparing the free base product with this 35% solution in water have not been performed. Nicotine is very hygroscopic and sensitive to light and oxygen. The brown color is due to exposure to either of these components. The product may be stored at ambient temperature. The freeze/thaw stability of this item has not been investigated.
Fortfahren mit
N1019
(−)-Nicotine hemisulfate salt
≥95% (TLC), ~35 % (w/v) in H2O (based on free base)
Synonym(e):
(−)-1-Methyl-2-(3-pyridyl)pyrrolidine
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 mL | Warenkorb auf Verfügbarkeit prüfen | € 53,70 |
100 mL | Warenkorb auf Verfügbarkeit prüfen | € 125,00 |
Über diesen Artikel
Lineare Formel:
(C10H14N2)2 · H2SO4
CAS-Nummer:
Molekulargewicht:
422.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
MDL number:
Assay:
≥95% (TLC)
Form:
liquid
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥95% (TLC)
form
liquid
concentration
~35 % (w/v) in H2O (based on free base)
color
dark brown
SMILES string
OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
InChI
1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
InChI key
IECQULMJVNSKDB-RCWTXCDDSA-N
Gene Information
human ... CHRNA4(1137), CHRNB2(1141)
General description
Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.
Application
(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.
Biochem/physiol Actions
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
Analysis Note
Mixture of nicotine base and nicotine sulfate.
Disclaimer
Shelf-life of the solution as supplied is at least six years when stored at room temperature.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥95% (TLC), ~35 % (w/v) in H2O (based on free base) | description ≥99% (GC), liquid | description ≥98% (TLC), liquid | description Potent agonist of the nicotinic acetylcholine receptor. |
| form liquid | form liquid | form liquid | form solid |
| assay ≥95% (TLC) | assay ≥99% (GC) | assay ≥98% (TLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| color dark brown | color yellow | color yellow | color white to off-white |
| concentration ~35 % (w/v) in H2O (based on free base) | concentration - | concentration - | concentration - |
| Gene Information human ... CHRNA4(1137), CHRNB2(1141) | Gene Information human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756) | Gene Information mouse ... Chrna1(11435), Chrna7(11441) | Gene Information - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Is this solution more stable than nicotine liquid alone? Does the brown colour imply the presence of oxidation of the free base nicotine? Is it sensitive to freeze-thaw cycles when diluted in distilled water and kept at -20? Thank you very much.
1 answer-
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