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M5525
4-(N-Maleimidomethyl)cyclohexan-Carboxylsäure N-hydroxysuccinimid-Ester
≥98%, powder
Synonym(e):
N-Succinimidyl-4-(maleinimidomethyl)-cyclohexancarboxylat, SMCC
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 38,30 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 115,00 | |
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | € 346,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C16H18N2O6
CAS-Nummer:
Molekulargewicht:
334.32
UNSPSC Code:
12352103
NACRES:
NC.07
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1555271
Assay:
≥98%
Form:
powder
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥98%
form
powder
reaction suitability
reagent type: linker
mp
180-182 °C (lit.)
solubility
chloroform: 50 mg/mL, DMF: soluble
functional group
NHS ester
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2
InChI
1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChI key
JJAHTWIKCUJRDK-UHFFFAOYSA-N
General description
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Application
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% | assay ≥98% | assay ≥98.0% (HPLC) | assay ≥95% |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| reaction suitability reagent type: linker | reaction suitability reagent type: linker | reaction suitability reagent type: linker | reaction suitability reagent type: cross-linking reagent |
| solubility chloroform: 50 mg/mL, DMF: soluble | solubility chloroform: 100 mg/mL, DMF: soluble (lit.)(lit.) | solubility - | solubility acetone: 50 mg/mL, DMF: soluble |
| mp 180-182 °C (lit.) | mp 70-73 °C (lit.) | mp 70-73 °C (lit.) | mp 84-86 °C (lit.) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Verwandter Inhalt
Ahmed H
Principles and Reactions of Protein Extraction, Purification, and Characterization (2004)
David A Elsemore et al.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 29(5), 645-653 (2017-04-21)
We report the development and field validation of 2 ELISAs for the detection of Ancylostoma caninum or Toxocara canis coproantigens in the feces of dogs with experimental and natural infections, and evidence of cross-reactivity with respective feline counterparts. A. caninum-specific
Dieke van Dinther et al.
Cancers, 11(2) (2019-02-16)
The lack of tumor-reactive T cells is one reason why immune checkpoint inhibitor therapies still fail in a significant proportion of melanoma patients. A vaccination that induces melanoma-specific T cells could potentially enhance the efficacy of immune checkpoint inhibitors. Here
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M5525-100MG | 04061834060062 |
| M5525-5MG | 04061832863047 |
| M5525-25MG | 04061832863030 |
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¿Qué caducidad se puede dar al producto M5525 almacenado a -20ºC?
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