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H7654

Hydroxyguanidine sulfate salt

Name: Hydroxyguanidine sulfate salt
Brand: SIGMA

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Über diesen Artikel

Lineare Formel:

CH₅N₃O · 1/2H₂SO₄

CAS-Nummer:

6345-29-5

Molekulargewicht:

124.11

NACRES:

NA.77

PubChem Substance ID:

329815245

UNSPSC Code:

12352202

EC Number:

228-749-0

MDL number:

MFCD00042033

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Eigenschaften

biological source

synthetic (organic)

assay

≥98% (TLC)

form

powder

solubility

water: 25 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

NC(=N)NO.NC(=N)NO.OS(O)(=O)=O

InChI

1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)

InChI key

MTGDDPZRXSDPFH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals.[1] Reacts with NO to form an adduct which is a potent and stable vasodilator.

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Dieser Artikel	A3134	C13408	D3179
Sigma-Aldrich H7654 Hydroxyguanidine sulfate salt	Sigma-Aldrich A3134 3-Aminopropionitrile fumarate salt	Sigma-Aldrich C13408 O-(Carboxymethyl)hydroxylamine hemihydrochloride	Sigma-Aldrich D3179 2-Deoxy-D-glucose
assay ≥98% (TLC)	assay ≥98% (TLC)	assay 98%	assay ≥98% (GC)
biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)
form powder	form powder	form crystalline powder, powder or crystals	form powder
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C
solubility water: 25 mg/mL, clear, colorless	solubility water: 50 mg/mL, clear, colorless to faintly yellow	solubility water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility H₂O: 1 M at 20 °C, clear, colorless

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO.

David Lefèvre-Groboillot et al.

The FEBS journal, 272(12), 3172-3183 (2005-06-16)

The binding of several alkyl- and aryl-guanidines and N-hydroxyguanidines to the oxygenase domain of inducible NO-synthase (iNOS(oxy)) was studied by UV/Vis difference spectroscopy. In a very general manner, monosubstituted guanidines exhibited affinities for iNOS(oxy) that were very close to those

Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase.

Patrick Slama et al.

Biochemical and biophysical research communications, 316(4), 1081-1087 (2004-03-27)

Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH). The reaction requires the presence of both molecular oxygen and a reducing cosubstrate, the assumed physiological cosubstrate being ascorbic acid. We have investigated the ability of a new

Alternative nitric oxide-producing substrates for NO synthases.

Daniel Mansuy et al.

Free radical biology & medicine, 37(8), 1105-1121 (2004-09-29)

Nitric oxide (NO) is a key inter- and intracellular molecule involved in the maintenance of vascular tone, neuronal signaling, and host response to infection. The biosynthesis of NO in mammals involves a two-step oxidation of L-arginine (L-Arg) to citrulline and

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Global Trade Item Number

SKU	GTIN
H7654-50MG	04061832947884

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