C5857

CA-074 methyl ester

≥99% (TLC)

• Synonym(e): (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
• Empirische Formel (Hill-System): C₁₉H₃₁N₃O₆
• CAS-Nummer: 147859-80-1
• Molekulargewicht: 397.47
• NACRES: NA.77
• PubChem Substance ID: 329775104
• UNSPSC Code: 12352108
• MDL number: MFCD03452890
• Assay: ≥99% (TLC)
• Form: solid
• Quality level: 100

Eigenschaften

• InChI: 1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
• SMILES string: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
• InChI key: XGWSRLSPWIEMLQ-RQLZCWDZSA-N
• biological source: synthetic (organic)
• assay: ≥99% (TLC)
• form: solid
• storage temp.: −20°C
• Quality Level: 100

Beschreibung

Application

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes,[1] HeLa cells[2] and human pancreatic cancer PANC-1 cells.[3]

Biochem/physiol Actions

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type.[4] and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.[5]

Features and Benefits

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Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)