SCC283

SF126 Human Glioblastoma Cell Line

SF126 human glioblastoma cell line is a suitable model for cellular physiology and chemosensitivity studies.

• NACRES: NA.81
• UNSPSC Code: 41106514

Eigenschaften

• application(s): cell analysis

Beschreibung

General description

Glioblastoma multiforme is the most common and malignant primary brain tumor, with a high recurrence rate and a five-year survival rate of less than 5% (1). Nearly 50% of glioblastomas originate in the frontal or temporal lobes of the brain (1). Glioblastomas are the most aggressive form of cancer, highlighting the importance of relevant human patient-derived cell models for advancing research into characteristics and treatment of this disease.

SF126 is a patient-derived glioblastoma cell line originating from a frontal lobe tumor (2). SF126 cells do not express the glial markers GFAP or glutamine synthetase but are positive for laminin and fibronectin expression in early passages, suggestive of proliferative or transformed mesenchymal cells of glioblastoma (2). SF126 cells exhibit hypertriploidy and fibroblastic morphology in culture and are non-tumorigenic in athymic mice (2).

<bold>Source:</bold>
The SF126 glioblastoma cell line was derived from the left frontal lobe tumor of a 50-year-old female patient (2).

Research Category:
Cancer

Application

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Human, Cancer Cells

Packaging

&ge;1X10⁶ cells/vial

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Analysis Note

• Each vial contains ≥1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

Other Notes

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact [email protected].

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable