Following reconstitution, retinoic acid may be stored at 2-8°C, -20°C, or -70°C for up to 2 weeks. Note that this material is sensitive to light, heat, and air when in solution. Store stock solutions under argon and protected from light. See the link below to review additional information povided for the SigmaAldrich brand of this compound:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/231/812/r2625pis.pdf
554720
trans-Retinsäure
Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.
Synonym(e):
trans-Retinsäure, Tretinoin, ATRA, Vitamin-A-Säure
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
500 mg | Warenkorb auf Verfügbarkeit prüfen | Anfragen |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H28O2
CAS-Nummer:
Molekulargewicht:
300.44
UNSPSC Code:
12352106
NACRES:
NA.21
MDL number:
Assay:
≥95% (by assay)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Technischer Dienst
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Unterstützung erhaltendescription
Merck USA index - 14, 8165
Quality Segment
assay
≥95% (by assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(CCCC1(C)C)C
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
General description
Leistungsstarker Wachstums- und Differenzierungsmodulator. Bindet an nukleäre Retinsäurerezeptoren (RAR), die direkt die Genexpression regulieren. Hemmt Melanozytenadhäsion, -motilität und -wachstum. Weist keratolytische Aktivität auf. Induziert die Differenzierung von Tumorzellen neuralen Ursprungs. Induziert Apoptose in akut promyelozytischen Krebszellen. VOR LUFT SCHÜTZEN.
Application
- All-trans-retinoic acid modulates glycolysis via H19 and telomerase: the role of mir-let-7a in estrogen receptor-positive breast cancer cells: Diese Studie zeigt, wie all-trans-Retinsäure die Glykolyse in Brustkrebszellen durch die Modulation von H19 und Telomerase beeinflusst, was ihr Potenzial in der Brustkrebstherapie belegt (El Habre et al., 2024).
- Retinoic acid tiers mitochondrial metabolism to Sertoli Cell-Mediated efferocytosis via a non-RAR-dependent mechanism: Die Studie untersucht die Rolle von Retinsäure bei der Verbindung des mitochondrialen Stoffwechsels mit der Efferozytose in Sertoli-Zellen und liefert Erkenntnisse über ihre nicht-RAR-abhängigen Mechanismen und möglichen Anwendungen in der Reproduktionsbiologie (Wu et al., 2024).
- Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer: In diesem Artikel werden die synergistischen Effekte der Kombination von all-trans-Retinsäure mit Tamoxifen bei der Hemmung des Ovarialkarzinoms erörtert. Dabei wird eine vielversprechende therapeutische Strategie für Patientinnen mit Ovarialkarzinom hervorgehoben (Xu et al., 2024).
Packaging
Verpackt unter inertem Gas
Preparation Note
Nach der Rekonstitution im Kühlschrank aufbewahren (bei 4 °;C). DMSO-Stammlösungen sind bei 4 °;C bis zu 2 Wochen haltbar.
Other Notes
Tosi, P., et al. 1994. Leuk. Lymphoma14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys.300, 684.
Labbaye, C., et al. 1993. Blood81, 475.
Sakashita, A., et al. 1993. Blood81, 1009.
Situ, R., et al. 1993. Dermatology186, 38.
Tini, M., et al. 1993. Genes Develop.7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci.17, 427.
Sharpe, C.R. 1991. Neuron7, 239.
Thaller, C. and Eichele, G. 1990. Nature345, 815.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys.300, 684.
Labbaye, C., et al. 1993. Blood81, 475.
Sakashita, A., et al. 1993. Blood81, 1009.
Situ, R., et al. 1993. Dermatology186, 38.
Tini, M., et al. 1993. Genes Develop.7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci.17, 427.
Sharpe, C.R. 1991. Neuron7, 239.
Thaller, C. and Eichele, G. 1990. Nature345, 815.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxizität: Gesundheitsschädlich und karzinogen/teratogen (E)
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥95% (by assay) | assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) |
| form solid | form powder | form solid | form lyophilized solid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename EDQM | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| storage condition OK to freeze, protect from light, desiccated (hygroscopic) | storage condition - | storage condition - | storage condition OK to freeze |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
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trans-Retinoic acid Q 554720 Millipore storage temperature for the powder is 2-8°C. how about after dissolved in DMSO? still 2-8°C? or change to −20°C? How long does it last after dissolve?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
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Can I reconstitute this product then aliquot and store at -20C for extended periods of time?
1 answer-
Freezing is acceptable. A stock solution of 0.01 M (3 mg/ml) Retinoic acid in absolute ethanol was stored at -70°C for up to two weeks, according to Ponzoni and Lanciotti in Neurochemistry, volume 54, page 540, 1990.
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