218753

Caspase-5 Inhibitor I

Single spot by TLC, solid, Caspase-5 inhibitor, Calbiochem^®

• Synonym(e): Caspase-5 Inhibitor I, Z-WE(OMe)HD(OMe)-FMK
• Empirische Formel (Hill-System): C₃₇H₄₂FN₇O₁₀
• Molekulargewicht: 763.77
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated

Eigenschaften

• Produktname: Caspase-5 Inhibitor I, Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Beschreibung

General description

A potent, cell-permeable and irreversible inhibitor of caspase-5 (ICE_rel-III, TY), as well as caspase-1 and caspase-4.

A potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.

Biochem/physiol Actions

Primary Target
caspase-1, caspase-4, caspase-5, caspase-8

Reversible: no

Cell permeable: yes

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.

Analysis Note

single spot by TLC

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.

Z-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable