This product is a 100 mM (10 mg/438 µl) solution of 5-Aza-2'-Deoxycytidine in DMSO. Mixing with additional DMSO is not necessary.
189826
5-Aza-2′-Desoxycytidin
≥98% (HPLC), liquid, DNA methyltransferase inhibitor, Calbiochem
Synonym(e):
InSolution 5-Aza-2′-Desoxycytidin, Decitabin
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 10 mg | Warenkorb auf Verfügbarkeit prüfen | € 153,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C8H12N4O4
CAS-Nummer:
Molekulargewicht:
228.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
€ 153,00
Warenkorb auf Verfügbarkeit prüfen
Technischer Dienst
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Unterstützung erhaltenProduktname
5-Aza-2′-Desoxycytidin, InSolution, ≥98%, DNA methyltransferase inhibitor
Quality Level
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
ambient
storage temp.
−20°C
SMILES string
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key
XAUDJQYHKZQPEU-UHFFFAOYSA-N
General description
Ein Cytosin-Analogon, das als DNA-Methyltransferaseinhibitor dient. Stellt Caspase-8-, Caspase-10-mRNA und die Proteinexpression sowie die TRAIL-Sensitivität (tumor necrosis factor-related apoptosis inducing ligand) in TRAIL-resistenten Zelllinien wieder her. Verstärkt auch die durch HDAC(Histondeacetylase)-Inhibitoren eingeleitete Apoptose. Die feste Form dieser Verbindung (Katalognr. 189825) ist auch erhältlich.
Packaging
Verpackt unter inertem Gas
Physical form
Eine 100-mmol/l-Lösung (10 mg/438 µl) von 5-Aza-2ʹ-desoxycytidin (Katalognr. 189825) in DMSO.
Other Notes
Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A. und Taylor, S.M. 1980. Cell20, 85.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A. und Taylor, S.M. 1980. Cell20, 85.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxizität: Zulassungsprüfung (Z)
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% |
| form liquid | form lyophilized | form solid | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| storage condition OK to freeze, protect from light, desiccated (hygroscopic) | storage condition OK to freeze | storage condition OK to freeze | storage condition - |
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signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Analysenzertifikate (COA)
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Verwandter Inhalt
Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 189826-10MG | 04055977222050 |
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