1332000

Hydroxyharnstoff

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): Hydroxycarbamid
• Lineare Formel: NH₂CONHOH
• CAS-Nummer: 127-07-1
• Molekulargewicht: 76.05
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750138
• MDL number: MFCD00007943
• Beilstein/REAXYS Number: 1741548

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: hydroxyurea
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... RRM1(6240), RRM2(6241), RRM2B(50484)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Anti-neoplastisch. Inaktiviert die Ribonukleosid-Reduktase durch Bildung eines freien Nitroxid-Radikals, das ein freies Tyrosyl-Radikal im aktiven Zentrum des Enzyms bindet. Dadurch wird die Synthese von Desoxynukleotiden blockiert, was die DNA-Synthese hemmt und die Synchronisation oder den Zelltod in der S-Phase induziert.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361
• pcodes: P201 - P280 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable