BP197

Hydroxycarbamid

British Pharmacopoeia (BP) Reference Standard

• Synonym(e): Hydroxyharnstoff, Hydroxycarbamid
• Lineare Formel: NH₂CONHOH
• CAS-Nummer: 127-07-1
• Molekulargewicht: 76.05
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 1741548
• MDL number: MFCD00007943

Eigenschaften

• grade: pharmaceutical primary standard
• API family: hydroxycarbamide
• form: solid
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... RRM1(6240), RRM2(6241), RRM2B(50484)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxycarbamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Hydroxycarbamide Capsules

Biochem/physiol Actions

Anti-neoplastisch. Inaktiviert die Ribonukleosid-Reduktase durch Bildung eines freien Nitroxid-Radikals, das ein freies Tyrosyl-Radikal im aktiven Zentrum des Enzyms bindet. Dadurch wird die Synthese von Desoxynukleotiden blockiert, was die DNA-Synthese hemmt und die Synchronisation oder den Zelltod in der S-Phase induziert.

Packaging

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable