1288463

Gemcitabin-Hydrochlorid -hydrochlorid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 2′-Desoxy-2′,2′-difluorcytidin; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
• Empirische Formel (Hill-System): C₉H₁₁F₂N₃O₄ · HCl
• CAS-Nummer: 122111-03-9
• Molekulargewicht: 299.66
• NACRES: NA.24
• PubChem Substance ID: 329749929
• UNSPSC Code: 41116107
• MDL number: MFCD01735988

Eigenschaften

• grade: pharmaceutical primary standard
• API family: gemcitabine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
• InChI: 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
• InChI key: OKKDEIYWILRZIA-OSZBKLCCSA-N
• Gene Information: human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

It is intended to be used as a USP reference standard in specified quality tests and assays.
Also used to prepare standard solutions in the assay and impurities analysis using LC-UV as described in the following United States Pharmacopeia (USP) monographs:

• Gemcitabine Hydrochloride
• Gemcitabine for Injection
  

Biochem/physiol Actions

Gemcitabin ist ein weit verbreiteter antineoplastischer Wirkstoff und Antimetabolit.

In Kliniken und Forschungslaboren ist Gemcitabin ein weit verbreiteter Antitumorwirkstoff. Es ist ein antineoplastischer Wirkstoff und Antimetabolit.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable