T9576

Picropodophyllotoxin

≥96% (HPLC), powder

• Synonym(e): (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, NSC 36407, PPP, Picropodophyllin
• Empirische Formel (Hill-System): C₂₂H₂₂O₈
• CAS-Nummer: 477-47-4
• Molekulargewicht: 414.41
• NACRES: NA.77
• PubChem Substance ID: 329826907
• UNSPSC Code: 12352200
• MDL number: MFCD01742647
• Assay: ≥96% (HPLC)
• Form: powder
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥96% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24
• InChI: 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
• InChI key: YJGVMLPVUAXIQN-HAEOHBJNSA-N
• Gene Information: human ... IGF1R(3480)

Beschreibung

Biochem/physiol Actions

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable[1].

Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

Features and Benefits

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Preparation Note

May contain 2-3% ethanol (w/w)

Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H312,H315,H319,H335
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges