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T8703
T0070907
≥98% (HPLC)
Synonym(e):
2-Chloro-5-nitro-N-4-pyridinyl-benzamide, Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 209,00 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 674,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C12H8ClN3O3
CAS-Nummer:
Molekulargewicht:
277.66
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2
InChI
1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChI key
FRPJSHKMZHWJBE-UHFFFAOYSA-N
General description
T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
Application
T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices[1]. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection[2].
T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
Biochem/physiol Actions
T0070907 is a PPAR-γ antagonist.
T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >10 mg/mL, H2O: insoluble | solubility DMSO: >15 mg/mL | solubility DMSO: >10 mg/mL | solubility DMSO: 25 mg/mL, clear |
| color white | color faintly yellow to dark yellow | color white to off-white | color white to beige |
Lagerklasse
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
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T0070907, a PPAR gamma inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe
An Z, et al.
Reproductive Sciences, 21(11), 1352-1361 (2014)
Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease
Li HD, et al.
International Immunopharmacology, 50, 95-106 (2017)
E M Schuman et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(25), 11958-11962 (1994-12-06)
Recent studies of long-term potentiation (LTP) in the CA1 region of the hippocampus have demonstrated that nitric oxide (NO) may be involved in some forms of LTP and have suggested that postsynaptically generated NO is a candidate to act as
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T8703-5MG | 04061833226940 |
| T8703-25MG | 04061833226933 |