Direkt zum Inhalt
Merck
Alle Fotos(1)

Wichtige Dokumente

C6499

Sigma-Aldrich

CTB

≥98% (HPLC)

Synonym(e):

CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

Größe auswählen

5 MG
€ 78,50
25 MG
€ 218,00

€ 78,50

Voraussichtliches Versanddatum06. April 2025

Bulk-Bestellung anfordern
Alle Fotos(1)

Größe auswählen

Ansicht ändern
5 MG
€ 78,50
25 MG
€ 218,00

About This Item

Empirische Formel (Hill-System):
C16H13ClF3NO2
CAS-Nummer:
451491-47-7
Molekulargewicht:
343.73
MDL-Nummer:
MFCD02356522
UNSPSC-Code:
12352200
NACRES:
NA.77

€ 78,50

Voraussichtliches Versanddatum06. April 2025

Bulk-Bestellung anfordern

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

2-8°C

SMILES String

FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl

InChIKey

YDXZSNHARVUYNM-UHFFFAOYSA-N

Allgemeine Beschreibung

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.[1]

Anwendung

CTB has been used to study its apoptotic effects on P53 protein acetylation.[2]

Biochem./physiol. Wirkung

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.
CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.[1]

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000139964
0000139964
0000188878
050M4611

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Willian S Korim et al.
Cardiovascular research, 115(6), 1092-1101 (2018-10-26)
Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are
Cory Chew et al.
Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)
Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and
DeMetris D Reed et al.
Meat science, 123, 205-210 (2016-10-19)
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines
Dastjerdi MN, et al.
Advanced Biomedical Research, 2 (2013)
Franklin D Echevarria et al.
Frontiers in neuroscience, 11, 318-318 (2017-06-18)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis
Alle zugehörigen Dokumente anzeigen

Artikel

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.