Fortfahren mit
SML1880
SPL-334
≥98% (HPLC)
Synonym(e):
4-{[2-[(2-Cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 418,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C22H15N3O3S2
CAS-Nummer:
Molekulargewicht:
433.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O
InChI key
UWWSCLNCHCROLL-UHFFFAOYSA-N
Biochem/physiol Actions
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR).
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/L, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 0.5 mg/mL, clear (warmed) |
| color white to beige | color white to beige | color white to beige | color white to light brown |
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
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Maria E Ferrini et al.
PloS one, 8(7), e70351-e70351 (2013-08-13)
Allergic asthma is characterized by Th2 type inflammation, leading to airway hyperresponsivenes, mucus hypersecretion and tissue remodeling. S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of intracellular levels of S-nitrosothiols. GSNOR activity has been shown to be
Irina G Luzina et al.
The Journal of pharmacology and experimental therapeutics, 355(1), 13-22 (2015-07-26)
Interstitial lung disease (ILD) characterized by pulmonary fibrosis and inflammation poses a substantial biomedical challenge due to often negative disease outcomes combined with the need to develop better, more effective therapies. We assessed the in vivo effect of administration of
Paresh C Sanghani et al.
The Journal of biological chemistry, 284(36), 24354-24362 (2009-07-15)
S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that GSNOR regulates the smooth muscle tone in airways and the function of beta-adrenergic receptors in lungs and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1880-25MG | 04061832725581 |
| SML1880-5MG | 04061832725598 |