SML0777

Oltipraz metabolite M2

≥98% (HPLC)

• Synonym(e): 7-Methyl-6,8-bis(methylthio)-pyrrolo[1,2-a]pyrazine
• Empirische Formel (Hill-System): C₁₀H₁₂N₂S₂
• CAS-Nummer: 84201-40-1
• Molekulargewicht: 224.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S(C)c1[n]2c(c(c1C)SC)C=NC=C2
• InChI: 1S/C10H12N2S2/c1-7-9(13-2)8-6-11-4-5-12(8)10(7)14-3/h4-6H,1-3H3
• InChI key: MYLBTCQBKAKUTJ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

M2 is a metabolite of the chemopreventive agent oltipraz. Oltipraz metabolite M2 has been shown to inhibit liver steatosis by inhibiting lipogenesis and enhancing mitochondrial function, including fuel oxidation. Oltipraz metabolite M2 acts as a potent inhibitor of LXRa transcriptional activity, and also AMPK activator inducing the phosphorylation of AMPK.

M2 is a metabolite of the chemopreventive agent oltipraz; LXRa inhibitor; AMPK activator.

Features and Benefits

This compound is featured on the AMPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Light sensitive and air sensitive.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable