Fortfahren mit
SML0152
AK-7
≥98% (HPLC)
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 98,10 € 83,38 |
Über diesen Artikel
Empirische Formel (Hill-System):
C19H21BrN2O3S
CAS-Nummer:
Molekulargewicht:
437.35
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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Unterstützung erhaltenQuality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
InChI
1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
InChI key
IYAYHZZWYNXHEQ-UHFFFAOYSA-N
General description
AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.
Application
AK-7 has been used in cell culture and cell treatment.
Biochem/physiol Actions
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥15 mg/mL | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility H2O: 20 mg/mL |
| color white to tan | color white to beige | color white to beige | color - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
Motyl J, et al.
Molecular Neurobiology, 55(1), 727-740 (2018)
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
Wang X,et al.
Drug design, development and therapy (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0152-5MG | 04061833221969 |
| SML0152-25MG | 04061833221952 |