I7016

H-7 -dihydrochlorid

≥98% (HPLC)

• Synonym(e): 1-(5-Isochinolinylsulfonyl)-2-methyl-piperazin -dihydrochlorid, Isochinolin-5-sulfonsäure-2-methyl-1-piperazid -dihydrochlorid
• Empirische Formel (Hill-System): C₁₄H₁₇N₃O₂S · 2HCl
• CAS-Nummer: 108930-17-2
• Molekulargewicht: 364.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24278496
• MDL number: MFCD00036961
• Beilstein/REAXYS Number: 5840763
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: H₂O: 20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
• InChI key: OARGPFMFRLLKPF-UHFFFAOYSA-N
• Gene Information: human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)

Beschreibung

General description

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

Application

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Disclaimer

Light sensitive

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)