SML1344

AK-1

≥98% (HPLC)

• Synonym(e): 3-[(Hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide
• Empirische Formel (Hill-System): C₁₉H₂₁N₃O₅S
• CAS-Nummer: 330461-64-8
• Molekulargewicht: 403.45
• MDL-Nummer: MFCD01122550
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825801
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=S(N1CCCCCC1)(C2=CC(C(NC3=CC=CC([N+]([O-])=O)=C3)=O)=CC=C2)=O
• InChI: 1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23)
• InChIKey: HAYBKCHPEBZNGW-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

AK-1 is a benzylsulfonamide. It acts as avia inhibiting of the nuclear factor-KB (NF-KB) /CSN2 (casein β) pathway.

AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable