SML0127

Longdaysin

≥98% (HPLC)

• Synonym(e): 9-isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
• Empirische Formel (Hill-System): C₁₆H₁₆F₃N₅
• CAS-Nummer: 1353867-91-0
• Molekulargewicht: 335.33
• NACRES: NA.77
• PubChem Substance ID: 329825177
• UNSPSC Code: 12352200
• MDL number: MFCD20527323
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)N(C=N1)C2=C1C(NCC3=CC(C(F)(F)F)=CC=C3)=NC=N2
• InChI: 1S/C16H16F3N5/c1-10(2)24-9-23-13-14(21-8-22-15(13)24)20-7-11-4-3-5-12(6-11)16(17,18)19/h3-6,8-10H,7H2,1-2H3,(H,20,21,22)
• InChI key: REKSFCCYDQMSIN-UHFFFAOYSA-N

Beschreibung

Application

Longdaysin may be used to study cell signaling that regulate the circadian clock and behavior.

Biochem/physiol Actions

Longdaysin inhibits CK1, ERK2, and CDK7 kinases in low mM concentrations. The activity of longdaysin results in a lengthening of circadian periods in cell based and in vivo systems. Transgenic zebrafish harboring a per3-luc reporter gene displayed a 10 hour lengthening of circadian period when treated with longdaysin. Longdaysin reduces the phosphorylation of PER1 the regulator of molecular clock function and manipulates the circadian clock.[1][2]

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H315,H319,H335,H361d
• pcodes: P202 - P261 - P264 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable