SML1385

Lomitapide

≥98% (HPLC), microsomal triglyceride transfer protein (MTP) inhibitor, powder

• Synonym(e): AEGR-733, BMS-201038, N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde
• Empirische Formel (Hill-System): C₃₉H₃₇F₆N₃O₂
• CAS-Nummer: 182431-12-5
• Molekulargewicht: 693.72
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825833
• NACRES: NA.77
• MDL number: MFCD16620494
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Lomitapide, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O
• InChI: 1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
• InChI key: MBBCVAKAJPKAKM-UHFFFAOYSA-N
• Gene Information: human ... MTTP(4547), P4HB(5034)

Beschreibung

Application

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Biochem/physiol Actions

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable