P8399

Psoralen

≥99% (HPLC)

• Synonym(e): 6,7-Furanocumarin, Ficusin, Furo[3,2-g]cumarin, Furo[3,2-g]benzopyran-7-on
• Empirische Formel (Hill-System): C₁₁H₆O₃
• CAS-Nummer: 66-97-7
• Molekulargewicht: 186.16
• Beilstein: 152784
• EG-Nummer: 200-639-7
• MDL-Nummer: MFCD00010520
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24898918
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder
• Fluoreszenz: λ_ex 335 nm; λ_em 460 nm (pH 7.0)
• Lagertemp.: 2-8°C
• SMILES String: O=C1Oc2cc3occc3cc2C=C1
• InChI: 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
• InChIKey: ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Beschreibung

Anwendung

Photochemisches Reagens zur Untersuchung von Nukleinsäurestruktur und -funktion.

Psoralen has been used:

• as a crosslinker for dsRNA for in- situ hybridization studies[1]
• in testing melanin dispersal effects in fish scale melanophores[2]
• to test its stimulatory effects in osteoblast a cell proliferation assay[3]
• as a reference standard in high-performance liquid chromatography (HPLC)[4]

Biochem./physiol. Wirkung

Psoralen belongs to the linear type furanocoumarins.[5] It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation.[5] This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma.[5] However, usage psoralen also leads to hepatotoxicity[6] and cytotoxicity by the generation of psoralen photoproducts (POPs).[7] It may be useful in treating osteoporosis[8]

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H317
• P-Sätze: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 4 Oral - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves