P7527

Prostaglandin E₁

powder, γ-irradiated, BioXtra, suitable for cell culture

• Synonym(e): (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-ensäure, Alprostadil, PGE₁
• Empirische Formel (Hill-System): C₂₀H₃₄O₅
• CAS-Nummer: 745-65-3
• Molekulargewicht: 354.48
• UNSPSC Code: 12352209
• NACRES: NA.77
• PubChem Substance ID: 24898855
• EC Number: 212-017-2
• Beilstein/REAXYS Number: 5294062
• MDL number: MFCD00077860
• eCl@ss: 42020658
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥60% (HPLC)

Eigenschaften

• Quality Level: 200
• InChI key: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• biological source: synthetic (organic)
• sterility: γ-irradiated
• product line: BioXtra
• assay: ≥60% (HPLC)
• form: powder
• concentration: ≥60% (HPLC)
• technique(s): cell culture | mammalian: suitable
• solubility: ethanol: 1 mg/mL
• storage temp.: −20°C
• Gene Information: human ... PTGER1(5731), PTGER2(5732), PTGIR(5739) ; mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

Beschreibung

Application

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Prostaglandin E1 has been used in maintaining mice proximal tubule,[1] and NRK-52E, a rat renal epithelial cell line.

Biochem/physiol Actions

Prostaglandins mediate vasodilation and vasoconstriction, the E series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. Prostaglandin E1 is considered as a potent pyretic factor, and acts through cerebral ventricles. Prostaglandin E1 is useful to prolong cardiovascular function in new born suffering from ductus-dependant congenital heart disease until surgery.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves