P8908

Prostaglandin E₁

synthetic, powder, BioReagent, suitable for cell culture

• Synonym(e): (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-ensäure, Alprostadil, PGE₁
• Empirische Formel (Hill-System): C₂₀H₃₄O₅
• CAS-Nummer: 745-65-3
• Molekulargewicht: 354.48
• UNSPSC Code: 12352209
• NACRES: NA.77
• PubChem Substance ID: 24898994
• EC Number: 212-017-2
• Beilstein/REAXYS Number: 5294062
• MDL number: MFCD00077860
• eCl@ss: 42020658
• Biological source: synthetic
• Form: powder
• Assay: ≥98% (HPLC)

Eigenschaften

• biological source: synthetic
• Quality Segment: 200
• product line: BioReagent
• assay: ≥98% (HPLC)
• form: powder
• potency: 0.25-100 ng/mL
• technique(s): cell culture | mammalian: suitable
• solubility: acetone: 10 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• InChI key: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• Gene Information: human ... PTGER1(5731), PTGER2(5732), PTGIR(5739) ; mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

Beschreibung

General description

Prostaglandin E₁ (PGE1) is a vasodilator.

Application

Prostaglandin E1 may be used in cell culture to protect human umbilical vein endothelial cells (HUVEC) from injury induced by hydrogen peroxide.

Biochem/physiol Actions

Prostaglandin E₁ (PGE1) aids in the relaxation of corporal cavernosal tissue. It helps to preserve the patency of the ductus arteriosus. It is used to treat erectile dysfunction (ED).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves