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N8010

4-Guanidino-benzoesäure-4-nitrophenylester -hydrochlorid

protease substrate, ≥95.0% (TLC), powder

Synonym(e):

4-Nitrophenyl-4-Guanidinobenzoat -hydrochlorid, pNPGB

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Über diesen Artikel

Empirische Formel (Hill-System):
C14H12N4O4 · HCl
CAS-Nummer:
19135-17-2
Molekulargewicht:
336.73
NACRES:
NA.32
PubChem Substance ID:
24897847
UNSPSC Code:
12352204
EC Number:
242-831-3
MDL number:
MFCD00037010
Beilstein/REAXYS Number:
8024554

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Produktname

4-Guanidino-benzoesäure-4-nitrophenylester -hydrochlorid, protease inhibitor and substrate

InChI key

PKSBDZOBYIKNGY-UHFFFAOYSA-N

InChI

1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H

SMILES string

Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O

assay

≥95.0% (TLC)

form

powder

solubility

formic acid: soluble 49.00-51.00 mg/mL

storage temp.

−20°C

Quality Level

200

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1 of 4

Dieser Artikel
N162773677N2127
4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate

Sigma-Aldrich

N8010

4-Nitrophenyl 4-guanidinobenzoate hydrochloride

4-Nitrophenyl β-D-glucuronide ≥98% (TLC)

Sigma-Aldrich

N1627

4-Nitrophenyl β-D-glucuronide

4-Nitrophenyl β-D-glucuronide ≥99.0% (TLC)

Sigma-Aldrich

73677

4-Nitrophenyl β-D-glucuronide

4-Nitrophenyl α-D-mannopyranoside α-mannosidase substrate

Sigma-Aldrich

N2127

4-Nitrophenyl α-D-mannopyranoside

assay

≥95.0% (TLC)

assay

≥98% (TLC)

assay

≥99.0% (TLC)

assay

≥98% (TLC)

solubility

formic acid: soluble 49.00-51.00 mg/mL

solubility

H2O: soluble 100 mg/mL, clear

solubility

H2O: 0.1 g/mL, clear, faintly yellow

solubility

DMF: 50 mg/mL

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

powder

form

powder or crystals

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.[1]

Application

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
  • as a substrate for trypsin for active site titration experiments
  • for pre-treating of mosquito eggs in the interplasmid transposition assay [2]
  • as a component of isotonic buffer to moisten filter paper for mosquito embryo collection[3]

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.[3]

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000427384
0000427384
0000361401
0000322468
0000322469

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S P Leytus et al.
Biochimica et biophysica acta, 788(1), 74-86 (1984-07-17)
A theory and experimental method are presented to characterize the kinetics of fast-acting, irreversible proteinase inhibitors. The theory is based upon formal analysis of the case of an irreversible inhibitor competing with a substrate for the active-site of a proteinase.
Mekdes Debela et al.
Scientific reports, 8(1), 10705-10705 (2018-07-18)
Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyzed with positional scanning using fluorogenic tetrapeptides and
D Collen et al.
The Journal of biological chemistry, 268(11), 8284-8289 (1993-04-15)
The mechanism of activation of human plasminogen by recombinant staphylokinase (STAR) was studied using the active site titrant p-nitrophenyl-p'-guanidinobenzoate (NPGB). NPGB prevented active site exposure in equimolar mixtures of plasminogen and STAR but reacted stoichiometrically with mixtures preincubated in the
Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes
STEVEN FS and GRIFFIN MM
European Journal of Biochemistry, 109(2), 567-573 (1980)
J E Dravland et al.
The Journal of experimental zoology, 232(1), 117-128 (1984-10-01)
Previous studies from this laboratory have suggested a role for sperm trypsinlike activity in the membrane events of the hamster sperm acrosome reaction, but these conclusions have been disputed by studies done with guinea pig, mouse, and ram sperm. This
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