L6293

LY-364947

≥98% (HPLC), Transforming Growth Factor-β Type I receptor kinase (ALK5) inhibitor, powder

• Synonym(e): 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline, HTS 466284, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
• Empirische Formel (Hill-System): C₁₇H₁₂N₄
• CAS-Nummer: 396129-53-6
• Molekulargewicht: 272.30
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724526
• NACRES: NA.77
• MDL number: MFCD00800758

Eigenschaften

• Produktname: LY-364947, ≥98% (HPLC)
• SMILES string: c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
• InChI key: IBCXZJCWDGCXQT-UHFFFAOYSA-N
• InChI: 1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100
• Gene Information: human ... TGFBR1(7046)

Beschreibung

Biochem/physiol Actions

LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC₅₀ = 59 nM. It is much less potent at related kinases, with IC₅₀ = 400 nM for TGF-β RII and IC₅₀ = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC₅₀ = 81 nM) in NIH 3T3 mouse fibroblasts.

Transforming Growth Factor-β Type I receptor kinase (ALK5) inhibitor

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges