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L1290

Sigma-Aldrich

Lactoferricin B, fragment 4-14 trifluoroacetate salt

≥95% (HPLC)

Synonym(e):

bLFC (26-36), bovine lactoferricin

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About This Item

Empirische Formel (Hill-System):
C70H113N25O13S
Molekulargewicht:
1544.87
MDL-Nummer:
MFCD04040902
UNSPSC-Code:
12352202
NACRES:
NA.32

Qualitätsniveau

200

Assay

≥95% (HPLC)

Löslichkeit

H2O: soluble

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

cell membrane | interferes

Lagertemp.

−20°C

Amino Acid Sequence

Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly

Allgemeine Beschreibung

Chemical structure: peptide

Anwendung

Lactoferricin B, fragment 4-14 trifluoroacetate salt has been used to study effect of lactoferricin on cell proliferation of human colon cancer cells. It has been used in study of ultraviolet light-mediated DNA damage in human colon cancer cells.

Biochem./physiol. Wirkung

Lactoferricin B also suppresses liver and lung metastasis in murine melanomas and lymphomas. In addition, it causes cell death in human leukemic and carcinoma cell lines. It is effective against Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Proteus vulgaris, Yersinia enterocolitica, Pseudomonas aeruginosa, Campylobacter jejuni, Staphylococcus aureus, Streptococcus mutans, Corynebacterium diphtheriae, Listeria monocytogenes and Clostridium perfringens.
Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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C Freiburghaus et al.
Journal of dairy science, 92(6), 2477-2484 (2009-05-19)
Food components modify the risk of cancer at a large number of sites but the mechanism of action is unknown. In the present investigation, we studied the effect of the peptide lactoferricin derived from bovine milk lactoferrin on human colon
Liv Tone Eliassen et al.
International journal of cancer, 119(3), 493-500 (2006-03-31)
Antimicrobial peptides have been shown to exert cytotoxic activity towards cancer cells through their ability to interact with negatively charged cell membranes. In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human
C Freiburghaus et al.
Journal of dairy science, 95(10), 5552-5560 (2012-08-21)
Treatment of Caco-2 cells with the peptide lactoferricin(4-14), results in reduction of the growth rate by prolongation of the S phase of the cell cycle. Lactoferricin(1-25) is formed in the gut by cleavage from lactoferrin and the bioactive amino acids
W Bellamy et al.
The Journal of applied bacteriology, 73(6), 472-479 (1992-12-01)
A physiologically diverse range of Gram-positive and Gram-negative bacteria was found to be susceptible to inhibition and inactivation by lactoferricin B, a peptide produced by gastric pepsin digestion of bovine lactoferrin. The list of susceptible organisms includes Escherichia coli, Salmonella

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