L1290

Lactoferricin B, fragment 4-14 trifluoroacetate salt

≥95% (HPLC)

• Synonym(e): bLFC (26-36), bovine lactoferricin
• Empirische Formel (Hill-System): C₇₀H₁₁₃N₂₅O₁₃S
• Molekulargewicht: 1544.87
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD04040902

Eigenschaften

• Quality Segment: 200
• assay: ≥95% (HPLC)
• solubility: H₂O: soluble
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell membrane | interferes
• storage temp.: −20°C

Beschreibung

General description

Chemical structure: peptide

Application

Lactoferricin B, fragment 4-14 trifluoroacetate salt has been used to study effect of lactoferricin on cell proliferation of human colon cancer cells.[1] It has been used in study of ultraviolet light-mediated DNA damage in human colon cancer cells.[2]

Biochem/physiol Actions

Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.

Lactoferricin B also suppresses liver and lung metastasis in murine melanomas and lymphomas. In addition, it causes cell death in human leukemic and carcinoma cell lines.[3] It is effective against Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Proteus vulgaris, Yersinia enterocolitica, Pseudomonas aeruginosa, Campylobacter jejuni, Staphylococcus aureus, Streptococcus mutans, Corynebacterium diphtheriae, Listeria monocytogenes and Clostridium perfringens.[4]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)